Anhedonia features a trans-diagnoctic character and really should be grasped as a complex occurrence, and it is important to correctly evaluate it within the framework of a certain study paradigm. It seems optimal to create several complementary research strategies that measure the most crucial «facets» of anhedonia, regardless of nosological type of the condition, in the framework of 1 study utilizing numerous techniques to seek out sufficient biomarkers of anhedonia seriousness (genetic, neuroimaging, biochemical). Given the high-quality organization of these comprehensive scientific studies based on the proper methodology of evidence-based medication, it is likely that significant biomarker methods are available in the long run, which, if replicated in independent samples, may be used to personalize the diagnosis and remedy for depression.The relevance associated with the research of demyelinating diseases is due to their increasing regularity in kids, clarification associated with the role of infectious representatives inside their genesis, as well as the likelihood of transformation of disseminated encephalomyelitis into numerous sclerosis. The literature review presents the currently available information about the causes of the development of demyelinating diseases, biomarkers of disseminated encephalomyelitis and multiple sclerosis, what causes an unfavorable course and feasible laboratory parameters showing the transition in one infection to another, which are often used as prognostic elements. The authors additionally noted the experience for the writers regarding the importance of sufficient etiopathogenetic treatment in altering the nature associated with the course of the condition, in certain, when guaranteeing the relationship involving the regularity of exacerbations of ADEM and MS utilizing the activation of herpesvirus attacks, programs of certain antiviral therapy are effective, along with pathogenetic therapy targeted at correcting endothelial dysfunction utilizing the Repertaxin drug cytoflavin.Cognitive impairment (CI) develops not only in structural damage to the central nervous system, but also in encephalopathies of dysmetabolic and deficiency etiology. Recently, unique attention is concentrated on the look of CI as a result of the scarcity of cobalamin (vitamin B12) and folic acid (FA), the change within the degree of homocysteine (HC). To identify vitamin B12 deficiency can be done by examining key biomarkers in serum based on a decrease in the levels of vitamin B12 and holotranscobalamin, and quantities of methylmalonic acid (MMA) and HC. This article provides an analysis of researches performed in Norway, Korea, Asia, along with other nations to assess the risks of CI within the presence of decreased degrees of vitamin B12 in the elderly, which demonstrated a decrease in brain volume within the senior (according to MRI data) in conjunction with altered test parameters that assess cognitive features. In lots of researches, feminine clients with minimal levels of vitamin B12 predominated among the list of examined customers. Also, some research reports have shown the potency of complex CI treatment aided by the inclusion of vitamin B12 (both for oral and intravenous management). Oral vitamin B12 therapy at a dose of 1000 μg has been confirmed is adequate when it comes to treatment of vitamin B12 deficiency. Additionally, the administration of vitamin B12 for prophylactic functions is recommended for customers with subnormal or borderline concentrations of vitamin B12 in the bloodstream serum. To review the possibility of employing the polypeptide drug cortexin for the treatment of intellectual, mental and behavioral problems in children and adolescents with epilepsy and also to measure the efficacy and protection associated with drug in this group of clients. Eighty-six clients (41 girls and 45 guys) had been analyzed at the chronilogical age of 3 to 17 y.o. Cortexin had been used along with antiepileptic medications. Clinical and pathopsychological methods were administered. Medical, neurophysiological and mental research of children and teenagers with epilepsy expose the enhancement of electrophysiological variables, there are not any aggravation of seizures in 95% cases. The improvement of intellectual functions is observed in 65% of patients.Medical, neurophysiological and psychological research of kiddies and adolescents with epilepsy expose the enhancement of electrophysiological parameters repeat biopsy , there aren’t any aggravation of seizures in 95% cases. The improvement of cognitive functions is seen in 65% of patients.A clinical case of a genetically confirmed analysis of alternating hemiplegia associated with epilepsy is provided. The combination of 2 kinds of seizures in a young child managed to get tough to make an analysis. Caused by video-EEG monitoring managed to make it feasible to know that a kid revealed both epileptic seizures and non-epileptic seizures simultaneously with various periodicities. The mutation within the ATP1A3 gene was Genetics research confirmed with genome-wide sequencing and targeted therapy was prescribed in a timely manner.