1%)achieved EVR, 67 ( 94.3% ) achieved ETVR. The rates of relapse were 17.9% on 24 week follow- up and 26.86% on 48 week follow-up. Univariate analysis showed that the rate of relapse was higher for age ≥50, gene type I,HCV RNA ≥ 1.0 × 10∧5copies/ml, HCV RNA in PBMC positive, liver fibrosis ≥S2 and leptin expression positive than for age <50, gene type non-I, HCV RNA<1.0 × 10∧5copies/ml, HCV RNA in PBMC negative, liver fibrosis

of transmission, RVR, EVR (χ2=0.19,0.46,0.16,0.06,P > 0.05, respectively). Multivariate logistic stepwise regression analysis BAY 57-1293 datasheet showed that gene type I, HCV RNA level and HCV RNA level in PBMC were independent factors for predicting

relapse[OR = 7.56(95%CI 1.418-40.311, OR = 7.553(95%CI 1.692-33.527, OR = 5.165(95%CI 1.102-24.210), P < 0.05, respectively]. Conclusion: Age, gene type, HCV RNA level, HCV RNA level in PBMC, liver fibrosis, leptin expression in liver were related with relapse. Gene type I, HCV RNA level and HCV RNA level in PBMC were independent factors for predicting relapse. Key Word(s): 1. Chronic hepatitis C; 2. Antiviral Erastin therapy; 3. relapse; 4. leptin; Presenting Author: CHING-CHUNG LIN Additional Authors: MING-JONG BAIR, CHIA-HSIEN WU, HUAN-LIN CHEN, I-TSUNG LIN, HORNG-YUAN WANG, SHOU-CHUAN SHIH Corresponding Author: CHING-CHUNG LIN Affiliations: Mackay Memorial Hospital Objective: The treatment efficacy of HCV genotype 1 is inferior to genotype 2 by peginterferon plus ribavirin, but it is unclear about the role of mixed-genotype 1 and 2. In recently, mixed genotype HCV infection could be detected, so a comprehensive and detailed investigation is worth to evaluate the clinical role. We compared the treatment outcome

of HCV genotype 1, genotype 2 and mixed-genotype 1 and 2 by peginterferon alfa-2b plus ribavirin in naïve chronic hepatitis C patients. Methods: In this retrospective case control study, total 150 patients (68 genotype 1, 55 genotype 2 and 27 mixed-genotype 1 and 2) were treated and received at least one dose medication, consisting peginterferon alfa-2b once weekly plus Paclitaxel supplier daily ribavirin (800 or 1000 mg, depending on body weight) for 24 weeks. The efficacy analysis was by intention to treat and endpoints including virological responses rate during the treatment and the influence of race. Results: Hepatitis C mixed-genotype 1 and 2 occupied about 20% of HCV treated patients in Taitung, Taiwan. There were no any differences in demographic and clinical characteristics among these 3 groups. There was significant difference in sustained virological response (SVR) rate between genotype 1 and genotype 2 (55.9% vs 83.6%; p = 0.001), and rapid virological response rate between genotype 1 and mixed-genotype 1 and 2 (64.7% vs 85.2%; p = 0.048).