Table 1 Relationships between expression of VEGFR-2, PDGFR-β, and C-met and clinicopathological factors Nutlin-3a manufacturer Parameters N VEGFR-2 P PDGFR-β P C-MET P High Low High Low High Low N(%) 93 80(86.0) 13   18(19.4) 75   75(80.6) 18   Gender                     Male 77 69(89.6) 8   15(19.5) 62   61(79.2) 16   Female 16 11(68.8) 5 0.044 3(18.8) 13 0.627 14(87.5) 2 0.355 Age                     ≤50 31 26(83.9) 5   6(19.4) 25   25(80.6) 6   >50 62 54(87.1) 8 0.448 12(19.4) 50 0.602

50(80.6) 12 0.616 HBsAg                     Positive 79 71(89.9) 8   16(20.3) 63   63(79.7) 16   Negative 14 9(64.3) 5 0.024 2(14.3) 12 0.461 12(85.7) 2 0.461 AFP(IU/ML)                     ≤400 47 39(83.0) 8   5(10.6) 42   39(83.0) 8   >400 46 41(89.1) 5 0.290 13(28.3) 33 0.029 36(78.3) 10 0.377 Tumor number                     Single 29 26(89.7) 3   2(6.9) 27   23(79.3) 6   >1 64 54(84.4) 10 0.371 16(25.0)

48 0.033 www.selleckchem.com/products/pci-32765.html 52(81.3) 12 0.516 Tumor size(cm)                     ≤5 16 13(81.3) 3   4(25.0) 12   13(81.3) 3   >5 77 67(87.0) 10 0.394 14(18.2) 63 0.373 62(80.5) 15 0.627 Differentiation                     High 26 26(100) 0   7(26.9) 19   21(80.8) 5   Middle 45 38(84.4) 7   6(13.3) 39   35(77.8) 10   Low 22 16(72.7) 6 0.023 5(22.7) 17 0.340 19(86.4) 3 0.705 Child-Pugh                     A 82 70(85.4) 12   14(17.1) 68   64(78.0) 18   B 11 10(90.9) 1 0.523 4(36.4) 7 0.134 11(100) 0 0.080 BCLC                     B 20 15(75.0) 5   2(10.0) 18   13(65.0) 7   C 73 65(89.0) 8 0.111 16(21.9) 57 0.194 62(84.9) 11 0.051 Hepatic cirrhosis                     Yes 48 45(93.8) 3   5(10.4) 43   37(77.1) 11   No 45 35(77.8) 10 0.026 13(28.9) 32 0.023 38(84.4) 7 0.263 Ascites                     Yes 19 17(89.5) 2   3(15.8) 16   17(89.5) Silibinin 2

  No 74 63(85.1) 11 0.476 15(20.3) 59 0.470 58(78.4) 16 0.228 Tumor thrombus                     Yes 38 33(86.8) 5   10(26.3) 28   34(89.5) 4   No 55 47(85.5) 8 0.551 8(14.5) 47( 0.126 41(74.5) 14 0.061 Extrahepatic metastasis                     Yes 48 43(89.6) 5   8(16.7) 40   40(83.3) 8   No 45 37(82.2) 8 0.235 10(22.2) 35 0.339 35(77.8) 10 0.339 VEGFR-2, vascular endothelial growth factor receptor-2; PDGFR-β, platelet-derived growth factor receptor-β; C-MET, hepatocyte growth factor receptor; HbsAg, hepatitis B surface antigen; AFP, serum alpha-fetoprotein; BCLC, Barcelona Clinic Liver Cancer stage.