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“Dear Editor, I and my co-authors acknowledge the many challenges of clinical studies of nutrients such as vitamin D [1], and appreciate that Dr Heaney [2] seems to agree with the limitations of our study as already pointed out in the discussion section of our paper [3]. Hopefully, ongoing or future studies will overcome these problems. Conflicts of interest None. References 1. Heaney RP (2008) Nutrition, endpoints and the problem of proof. J Nutr 138(9):1591–1595PubMed 2. Heaney RP (2011) The effect of vitamin D dose on bone mineral

density. Osteoporos Int. doi:10.​1007/​s00198-011-1844-2 3. Grimnes G, Joakimsen R, Figenschau Y, Torjesen PA, Almås B, Jorde R (2011) The effect of Cyclin-dependent kinase 3 high-dose vitamin D on bone mineral density and bone turnover markers in postmenopausal women with low bone mass − a randomized controlled 1-year trial. Osteoporos Int. doi:10.​1007/​s00198-011-1752-5, Epub ahead of print 10 September 2011″
“Introduction Osteoporosis is a bone disorder characterised by low bone density associated with a deterioration in bone quality (architecture, turnover, damage accumulation, and mineralization) resulting in an increase in bone fragility [1]. This leads to an increase in the risk of fractures, particularly of the hip and vertebrae, which is associated with elevated morbidity and mortality [2–4]. Osteoporosis affects one woman in three after menopause [5] and is recognised by the WHO as a major public health problem for prevention, diagnosis, and treatment.