9%] vs find more 1.43 [12.5%]). Those receiving multiple doses of corticosteroids also weighed less at birth than those exposed to placebo (221.6 g vs 2330 g, p=0.0026), were shorter (44.5 cm vs 45.4 cm, p<0 . 001.), and had a smaller head circumference (31. 1 cm vs 31.7 cm, p<0 . 001).

Interpretation

Multiple courses of antenatal corticosteroids, every 14 days, do not improve preterm-birth Outcomes, and are associated with a decreased weight, length, and head circumference at birth. Therefore, this treatment schedule is not recommended.

Funding Canadian Institutes of Health Research.”
“N-methyl-D-aspartate (NMDA) receptors are clustered at synapses via their association with the PSD-95 (postsynaptic density-95) Selleckchem ARN-509 membrane associated guanylate kinase (MAGUK) family of scaffolding proteins. PSD-95 is the best characterized of this family. It is known to associate with NMDA receptor NR2 subunits via a conserved ES(E/D)V amino acid sequence located at their C-termini and thus to promote the clustering, regulation

and the trafficking of assembled NR1/NR2 NMDA receptors at synapses. Here we have investigated in more detail NMDA receptor NR2/PSD-95 protein-protein association. Wild-type NR1 and PSD-95 alpha were co-expressed with a series of rodent C-terminal truncated constructs of either NR2A or NR2B subunits in human embryonic kidney (HEK) 293 cells and the association of PSD-95 alpha with assembled receptors determined by immunoprecipitation. Additional PSD-95 binding domains that differed between NR2A and NR2B subunits were identified. These domains mapped to the amino acid sequences NR2A (1382-1420)

and NR2B (1086-1157). These results suggest that NR2A and NR2B may associate with PSD-95 but with different affinities. This may be important in the determination of the lateral mobility of NMDA receptor subtypes in post-synaptic membranes. (C) 2009 IBRO. Published by Elsevier Ltd. All rights reserved.”
“Recent to research suggests that drug-related memories are reactivated after exposure to environmental cues and may undergo reconsolidation, a process that can strengthen memories. Conversely, reconsolidation may be disrupted by certain pharmacological agents such that the drug-associated memory is weakened. Several studies have demonstrated disruption of memory reconsolidation using a drug-induced conditioned place preference (CPP) task, but no studies have explored whether cocaine-associated memories can be similarly disrupted in cocaine self-administering animals after a cocaine priming injection, which powerfully reinstates drug-seeking behavior. Here we used cocaine-induced CPP and cocaine self-administration to investigate whether the N-methyl-D-aspartate receptor antagonist (+)-5methyl- 10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine maleate (MK-801) given just prior to reactivation sessions would suppress subsequent cocaine-primed reinstatement (disruption of reconsolidation). Systemic injection of MK-801 (0.05 or 0.