57%) children in the comparison cohort died. For children up to 5 years old, exposure to maternal PD was independently associated with a 1.47-fold [95% confidence interval (CI) 1.16-1.87] increased mortality risk, after adjusting for family income, urbanization level and the characteristics of mother, father and infant. The risk of death by unnatural causes was even higher (about 2.23 times the risk, 95% CI 1.34-3.70) among exposed offspring.

Conclusions. PD places preschool children at significantly increased risk of mortality, especially LCL161 from unnatural causes of death.”
“Background. Empathy is crucial for successful social relationships. Despite its importance

for social interactions, little is known about empathy in schizophrenia. This study investigated the degree to which schizophrenia patients can accurately infer the affective state of another person (i.e. empathic accuracy).

Method. A group of 30 schizophrenia patients and 22 healthy controls performed an empathic accuracy task on which they continuously rated the affective state of another person shown in a video (referred to as the ‘target’). These ratings were compared with the target’s own continuous self-rating of affective state; empathic accuracy was defined as the correlation between participants’

ratings and the targets’ self-ratings. A separate line-tracking this website task was administered to measure motoric/attentional factors that could account for group differences in performance. Participants’ self-rated empathy was measured using the Interpersonal Reactivity Index, and targets’ self-rated emotional expressivity was measured using the Berkeley Expressivity

Questionnaire.

Results. Compared with controls, schizophrenia patients showed lower empathic accuracy although they performed the motoric tracking task at high accuracy. There was a significant group x target expressivity interaction such that patients showed a smaller increase in empathic accuracy with higher levels of emotional expressivity by the target, compared with controls. Patients’ empathic accuracy was uncorrelated with AZD2014 mouse self-reported empathy or clinical symptoms.

Conclusions. Schizophrenia patients showed lower empathic accuracy than controls, and their empathic accuracy was less influenced by the emotional expressivity of the target. These findings suggest that schizophrenia patients benefit less from social cues of another person when making an empathic judgement.”
“Background. Hypothalamic-pituitary-adrenocortical (HPA) axis abnormalities have been found in patients with a psychotic disorder and first-degree relatives of patients with a psychotic disorder react with subtle increases in non-clinical psychotic experiences and negative emotions in the face of everyday stress.