Comparative FLAIR and volumetric analyses yielded 89% and 78% accuracies, respectively. A multi-modality analysis did not generate a higher accuracy (89%). A quantitative anatomically compartmented approach to SPECT analysis yields a particularly high lateralization accuracy in the case of mTLE comparable to that of quantitative FLAIR MR imaging. Hippocampal segmentation in this regard correlates well with ictal origin and shows good reliability in the preoperative analysis. (c) 2011 Elsevier B.V. All rights reserved.”
“We describe a distant

check details homologue of the fungal HET-s prion, which is found in the fungus Fusarium graminearum. The domain FgHET-s(218-289), which corresponds to the prion domain in HET-s from Podospora anserina, forms amyloid fibrils in vitro and is able to efficiently cross-seed HET-s(218-289) prion formation. We structurally characterize FgHET-s(218-289), which displays 38% sequence

identity with HET-s(218-289). Solid-state NMR and hydrogen/deuterium exchange detected by NMR show that the fold and a number of structural details are very similar for the prion domains of the two proteins. This structural similarity readily explains why cross-seeding occurs here in spite of A-1331852 the sequence divergence. (C) 2010 Elsevier Ltd. All rights reserved.”
“Many studies have investigated the consequences of individual variation in resting metabolic rate at thermoneutrality (RMRt) on reproductive performance. Despite strong theoretical reasons for expecting

such an association, results have generally been disappointing. A fundamental assumption of these studies is that RMRt is a repeatable trait. We examined repeatability of RMRt in female MF1 mice over short (15 days apart; N=238) and long intervals (110 days apart; N=33). In the long-term experiment, after the first RMRt measurement, females were separated in two groups: the first was kept virgin (N=16); CT99021 cost the second was allowed to breed (N=17) and measured 15 days after they had weaned their pups. We also examined the association between RMRt and reproduction. We used Pearson’s correlation (r) and intraclass correlation coefficients (rho) to estimate repeatability. There was a strong effect of body mass on RMRt for all measurements. Over the short interval, repeatability was significant for body mass (r=0.86; rho=0.86), RMRt (r=0.68; rho=0.68,) and residual-RMRt (r=0.58; rho=0.58). Over long intervals, repeatability of residual-RMRt was high in virgin females (r=0.59; rho=0.60), but not in the breeders (r=0.38; rho=0.39); body mass was repeatable only for non-breeders measured by r (r=0.55). There was no significant correlation between RMRt or residual-RMRt and litter size or litter mass. In conclusion, RMRt and residual-RMRt are highly repeatable traits in virgin MF1 female mice.