2 Infection caused by Candida sp. was confirmed by positive culture of the blood or device lead or on the basis of consistent histopathological studies. The appropriate management of persons with PPM/ICD infections has been described by Sohail et al. [7] and the current approach to patients with CRMD Candida infections was recently defined by Pappas et al. [15]. From publications spanning a 40-year period (1969–2009), we documented 15 patients, including our current case, with well-defined CRMD-associated Candida endocarditis (12 PPM, 3 ICD; Table 1). All were men with a mean age of 65.1 years (range = 38–87 years). Use of device prior to infection was documented for 13 patients and varied widely

from <1 month to 16 years. Manipulation of the CRMD within 3 months of infection (generator change) occurred in two patients. Infection symptoms were defined for 13 selleck screening library patients and fever was present in 10. All patients had lead vegetations and vegetation size ranged from 0.5 to 7 cm. Four patients experienced a major fungal embolus

to a pulmonary artery with C. albicans recovered from three of these and C. parapsilosis from one. Microbiology results revealed C. albicans (seven patients), C. parapsilosis (four patients), Candida tropicalis (two patients) and Candida glabrata (two patients). Included Daporinad in vivo in these results are one patient with both C. albicans and C. glabrata16 and one case where both C. albicans and Staphylococcus epidermidis were isolated.17 In one case, blood cultures were negative but histopathology at the time of autopsy was consistent with CRMD Candida endocarditis.18 Antimicrobial interventions varied with five patients receiving an amphotericin B formulation alone, two received amphotericin B with 5-flucytosine, four received fluconazole alone, therapy was undefined for two patients, one patient received

only antibacterial therapy18 and one patient received an echinocandin agent (caspofungin) Ketotifen followed by fluconazole and posaconazole.19 Twelve patients underwent CRMD explantation as part of the management of Candida endocarditis (five thoracotomy, three percutaneous extractions, four methods undefined), one patient refused surgical intervention, one was felt not to be a candidate for explantation and one expired without intervention. Eight of the 15 patients (53%) died whilst receiving treatment for infection. Amongst the 10 patients who received clearly documented anti-fungal therapy and also underwent CRMD explantation, there were two deaths (20%) that could be attributed to the Candida endocarditis. The number of hospitalisations associated with CRMD infections increased substantially in the United States during a 7-year period (1996–2003) when a 49% rise in CRMD implantations occurred.1 Increase in infection occurred in both PPM and ICD populations, and the complication increased the risk of in-hospital death by over twofold.