coli isolates than GDC0068 in non-CTX-M producers, as the CTX-M producers especially CTX-M-15 ones were significantly associated to phylogenetic group B2. Of note, the ST131
isolates didn’t exhibit the same virulence profiles. Only five different virulence genes were uniformly present in all 24 ST131 isolates, including fimH, iha, sat, fyuA, iutA genes and only 16 ST131 isolates belonged to 3 unique virulence profiles. The virulence profiles corresponded inconsistently with PFGE type, suggesting ongoing evolution of virulence genotypes. coli isolates Virulence factors Total CTX-M producers Non CTX-M producers AZD0530 manufacturer CTX-M-15 producers CTX-M-15 B2 producers B2 non-ST131 B2 ST131 CTX-M-15 B2 ST131producers N = 163 (%) N =
118 N = 45 N = 101 N = 52 N = 37 N = 24 N = 23 Total 910 730 180 671 463 332 193 186 Mean 5.58 6.18 4.0 6.64 8.90 8.97 8.04 8.08 Adhesin 3 (1.8) 2 (1.6) 1 (2.2) 2 (1.9) – 1 (2.7) – - papG I papG II 21 (12.8) 19 (16.1) * 2 (4.4) 19 (18.8)‡ 15 (28.8) † 10 (27.2) 5 (20.8) 5 (21.7) papG III 36 (22.0) 30 (25.4) 6 (13.3) 30 (29.7) ‡ 25 (48.0) † 24 (64.8) γ 4 (16.6) 4 (17.3) papC 35 (21.4) 29 (24.5) 6 (13.3) 29 (28.7) ‡ 25 (48.0) † 25 (67.5) γ 3 (12.5) 3 (13) fimH 138 (84.7) 100 (84.7) 38 (84.4) 85 (84.2) 51 (98.1) † 36 (97.3) 24 (100) 23 (100) afa/draBC 8 (4.9) 4 (3.3) 4 (8.8) 4 (3.9) 2 (3.8) 3 (8.1) 1 (4.1) 1 (4.3) sfa/foc 26 (15.9)
20 (16.9) 6 (13.3) 20 (19.8) ‡ 18 (34.6) † 22 (59.4) γ – - iha 49 (30.0) 45 (38.1) * 4 (8.8) 43 (42.5) ‡ 36 (69.2) † 14 (37.8) γ 24 (100) 23 (100) hra 38 (23.3) 29 (24.5) 9 (20.0) 28 (27.7) 19 (36.5) † 24 (64.8) γ – - Iron uptake 104 (63.8) 78 (66.1) 26 (57.7) Fenbendazole 68 (67.3) 49 (94.2) † 33 (89.1) 24 (100) 23 (100) fyuA iutA 82 (50.3) 65 (55.0) * 17 (37.7) 60 (59.4) ‡ 37 (71.2) † 16 (43.2) γ 24 (100) 23 (100) Toxin 27 (16.5) 24 (20.3) * 3 (6.6) 23 (22.8) ‡ 22 (42.3) † 24 (64.9) γ 2 (8.3) 2 (8.6) hylA cnfI 19 (11.6) 17 (14.4) 2 (4.4) 17 (16.8) ‡ 14 (26.9) † 15 (40.5) γ – - sat 38 (23.3) 37 (31.3) * 1 (2.2) 35 (34.6) ‡ 30 (57.6) † 8 (21.6) γ 24 (100) 23 (100) Cell protection 119 (73.0) 94 (79.6) * 25 (55.5) 84 (83.2) ‡ 40 (76.9) 28 (75.5) 18 (75) 18 (78.2) traT kpsM II 69 (42.3) 64 (54.2) * 5 (11.1) 59 (58.4) ‡ 45 (86.5) † 27 (72.9) γ 23 (95.8) 22 (95.