Descriptive data were presented as mean ± SD or median (range), as appropriate. Two- sided Student’s t-test, with 95% of confidence interval, was used for parametric variables, and the Mann-Whitney test was used for non-parametric variables. Categorical variables were compared through the mid-p exact test. Sensitivity, specificity, positive and negative predictive values, and positive and negative likelihood ratios (LR) were calculated with 95% confidence interval, in order to evaluate whether aEEG learn more is a predictive tool for short-term neurological evolution for

all patients, regardless of the diagnosis. During the study period; 2,196 patients were born at this center and 118 were transferred from other centers. Of these, 225 term neonates were hospitalized in the NICU. Twenty-one newborns

were monitored, this website of whom 13 were outborns. The diagnoses of the patients included were: neonatal encephalopathy in 12 newborns (five began hypothermia protocol), pulmonary hypertension secondary to RDS in eight (four began ECMO), and one with suspected neonatal seizures. The gestational age was 38.6 ± 1.4 weeks (mean ± SD). Monitoring started at 10 (4-20) hours [median (PC25-PC75)] of life, and the mean duration of monitoring was 54 (27-120) hours; 1,626 hours of monitoring were obtained. None of the patients died during the study period. Patients’ demographic and clinical characteristics are described on Table 1. Of the 21 patients studied, ten presented altered short-term neurological outcome as defined through clinical, EEG, and/or altered neuroimaging criteria. The neurological abnormal babies had lower Apgar scores at five minutes than the normal group, and were more likely to develop seizures during evolution. The group of abnormal neurological outcome was mostly represented by encephalopathy patients, but the difference was not statistically significant. The three patients who were not encephalopathic at this group, also had a complicated neurological course, but this did not appear to be attributable to Vasopressin Receptor an ischemic perinatal hypoxic

event. aEEG was abnormal in nine of these ten newborns (sensitivity of 90%, 95% CI: 59.6-98.2).Of the 11 neurologically normal patients, nine also had a completely normal aEEG (specificity of 82%, 95% CI: 52.3-94.9). The positive predictive value was 82% (95% CI: 52.3-94.9) and the negative predictive value was 90% (95% CI: 59.6-98.2). The positive LR was 4.95 (95% CI: 1.81-13.51) and the negative LR was 0.12 (95% CI: 0.02-0.91). 48% of the newborns started with a normal aEEG pattern and progressed normally until the end of the study. None of them had seizures. The recordings showed that abnormal type 2, 3, 4, and 5 aEEG patterns were more likely to continue to be altered. 38% of the children had seizures during monitoring.