Its frequency shows great ethnic and geographic variations The a

Its frequency shows great ethnic and geographic variations. The aim of this work is to determine the frequency of MTHFR 677 C-T and coexistence of MTHFR 677 C-T with 2 other common, hereditary thrombophilia causes-namely, factor V 1691 G-A and prothrombin (PT) 20210 G-A mutation-in the Setif region of Algeria. Selleck MEK inhibitor The study involved 147 apparently healthy participants (82 men and 65 women). Genotyping was carried out by a real-time polymerase chain

reaction. The MTHFR 677T carrier frequency was found to be 54.4% (80/147); 59 individuals were heterozygous (40.1%), and 21 were homozygous (14.3%). The frequency of MTHFR 677T was found to be 34.3%. Among the 147 individuals, 3 (2.0%) had factor V Leiden, LEE011 order and 5 (3.4%) had PT 202 10 A mutation. Of the 80 participants with MTHFR 677T mutation, 2 had heterozygote factor V 1691 G-A gene mutation, and 4 had heterozygote PT 202 10 G-A gene mutation. The results showed that MTHFR 677T prevalence is quite high: an allelic frequency of 34.3% with a genotype frequency

of 14.3%. Factor V 1691 G-A and PT 20210 G-A gene Mutations are rare in the healthy population of the Setif region of Algeria.”
“Objective: While a significant number of cancer patients experience distress only a minority are offered appropriate psychosocial interventions. Untreated distress can interfere with compliance to treatment and quality of life. The purpose of this study was to evaluate the psychometric properties and feasibility PLX-4720 molecular weight of the Icelandic translation of the Distress Thermometer (DT)

and Problem List, a tool developed to screen for distress in cancer patients. ?Methods: Participants were 149 cancer patients receiving treatment at outpatient oncology clinics at Landspitali-The National University Hospital of Iceland, mean +/- SD age 59.06 years +/- 12.92. Participants answered the DT, HADS and GHQ-30, demographic questions and questions regarding the DT. ?Results: Scores on the DT ranged from 0 to 10 with a mean +/- SD score of 3.09 +/- 2.40, 7.30 +/- 4.86 on HADS and 5.28 +/- 5.60 on GHQ-30. Significant correlations were between the DT and all categories on the Problem List as well as between the DT and HADS (r = 0.45), and between DT and GHQ-30 (r = 0.57). ROC-analysis supported that a cut-off point of 3 gives the best sensitivity and specificity for the DT predicting depression or anxiety according to the HADS and GHQ. Sixty-nine (48.3%) patients scored ?2 on DT and 74 (51.7%) scored =3. ?Conclusion: The Icelandic version of the DT is a valid instrument to screen for distress in clinical practice. The study adds to a growing literature suggesting that this brief instrument may aid in identifying cancer patients suffering from distress and consequently providing appropriate treatment. Copyright (c) 2011 John Wiley & Sons, Ltd.”
“(PACE 2009; 32:S32-S40).

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