Questions about adolescents’ self-reported physical and mental health status and their experiences with these life domains require more research attention so as to target appropriate supportive services, particularly for adolescents with mental or physical health challenges.”
“Obesity adversely affects health-related quality of life (HRQoL). Most studies have used body mass index (BMI) to measure obesity. Other measures of obesity, such as waist circumference HIF-1�� pathway (WC) or waist-to-hip ratio (WHR), may be better

predictors of cardiovascular disease and mortality. We, therefore, examined the associations between other anthropometric measures and HRQoL in a multi-ethnic

Asian population.

In this follow-up study from four previous cross-sectional surveys, HRQoL was measured, at follow-up, using the Short-Form 36 version 2 (SF-36v2) questionnaire. Linear regression was used to assess the relationship between anthropometric measures [BMI, WC, waist residuals (WR) (generated by regressing WC on BMI), WHR, waist-to-height ratio (WHtR) and height (Ht)] and HRQoL. We compared the models’ R (2), Akaike’s information criteria (AIC), and Schwarz Bayesian information criteria (BIC) from the different models.

Among 4,981 subjects, 47.6 % were men aged Combretastatin A4 molecular weight 50.6 +/- A 12.2 and women aged 49.3 +/- A 11.6 years. All gender-specific anthropometric measures were significantly correlated with BMI, except WR. After adjusting for known determinants of HRQoL, we found significant associations between BMI, WC and WHtR with SF-36v2 Physical Component Summary (PCS) scores in women but not men. In contrast, after adjusting for known determinants of HRQoL, WR and WHR were significantly associated with SF-36v2 Mental Component Summary (MCS) scores in men, but not women. RA(2), AIC and BIC were similar for all anthropometric measures in the final model.

The associations between measures

of central obesity and HRQoL differed between men and women. In women, associations were seen with SF-36v2 PCS, but measures of central obesity did not have significant Acadesine in vitro associations with HRQoL after controlling for BMI. In men, an association between WC and SF-36v2 MCS was statistically significant independent of BMI. These gender differences require further investigation.”
“Decreased paraoxonase-1 (PON1) activity has been associated with rheumatoid arthritis. There are two polymorphisms in serum PON1; one differs in the amino acid at position 192 (Q192R) and the other one differs at position 55 (L55M). We looked for a possible association between Q192R polymorphism and rheumatoid arthritis.